Adenomyoepithelioma (AME) with myoepithelial carcinoma of the breast is rare and diagnosed following histological and immunohistochemical analysis. In the present case study, we describe a 38-year-old female patient with malignant AME with ultrasonographic and core biopsy findings. Histopathology revealed biphasic tubular proliferation and epithelial cells with atypical nuclei with obvious pleomorphism, hyperchromasia, and frequent mitosis. Overall Ki-67 proliferation index reached 30%. The pat...
- Issue: 3, Volume: 1
A large number of genomic and post-genomic studies in this century have been conducted to provide insight into the molecular mechanisms of gastrointestinal carcinogenesis and precision medicine. However, the incidence and mortality associated with gastrointestinal cancer have been increasing in the higher age range. Here, this review presents preemptive medicine to delay or prevent the onset of gastrointestinal cancer through an intervention based on molecular biomarkers, including an individua...
- Issue: 2, Volume: 1
The weight loss is a common clinical condition occurred in patients with oesophageal cancer and it was present in 57% of patients at the time of diagnosis . This weight loss is related to malignancy and insufficient oral intake secondary to dysphagia, and it can be increased by neoadjuvant therapies. The weight loss can persist at least 3 years after surgery . Therefore, surgical patient candidate for oesophageal surgery should be nutritionally evaluated before the time of surgery to dete...
Extensive Refractory Isolated Multiple Nodal Recurrence of Ovarian Cancer Treated with Rapid Arc Radiotherapy Technique: A Case Series Study
Isolated nodal recurrence of ovarian cancer is infrequent. For selected patients cytoreductive surgery can improve the survival. The response rate for second line chemotherapy for recurrent ovarian cancer is around 50%–60%, 20%–30% and 10% in platinum-sensitive, platinum-resistant and platinum-refractory patients respectively. IMRT uses a computer algorithm to optimize dose to the target and minimize dose to organs at risk by modulating and shaping the beam either with static or dynamic beams.
In Extramedullary multiple myeloma, muscular involvement not adjacent to bone lesions (Especially multiple and diffuse) is rare. We report a case of multiple myleoma with multiple-diffuse muscle involvement confirmed by biopsy.
Prevalence and Patterns of Gastrointestinal Cancers among Obese Patients, from a Teaching Hospital in Saudi Arabia
Objective: To determine the prevalence and patterns of gastrointestinal (GI) cancers among obese and non-obese patients. Background: Obesity is associated with many comorbidities. Several studies concluded that there is an association between obesity and different types of cancers. But the prevalence and patterns of GI cancers among obese patients need to be investigated.
More than 100 types of papillomavirus have been identified so far, they are completely tissue-specific. About 5 of these infect the genital area from one person to another through sexual contact. Delayed proteins include L1 and L2, which form the virus capsid. Cervical cancer is the second most common cancer after breast cancer in women worldwide. Human papillomavirus (HPV) accounts for more than 2% of cervical cancers.Among them, about 15 carcinogenic genotypes have been identified as high-ris...
- Issue: 1, Volume: 1
Refining Immunotherapy of Human B-cell Non-Hodgkin’s Lymphoma by CD19 CAR T Cell: Current and Future Perspectives
Non-Hodgkin’s Lymphoma (NHL) is responsible for 4% of all cancer cases in the United States, but its conventional treatment options have experienced limited success. Patients develop resistances to the standard chemotherapy, CHOP, as well as Rituximab, a chemosensitizing agent used in concert with CHOP. Chimeric antigen receptor T cell (CAR-T cell) therapy may be a viable option for patients with refractory/relapsed NHL. In this new immunotherapy, a CAR is genetically added to the surface of T ...
Background and purpose: Stereotactic Ablative Radiotherapy (SART) has been associated with both impressive early responses and high rates of early-stage NSCLC control. This article reviews the overall survival, local control, toxicity and failure of SART in patients with early-stage NSCLC. Material and methods: The systematic review was performed following PRISMA guidelines. Survival outcomes were evaluated for early-stage NSCLC. Local control and toxicity outcomes were evaluated for any centr...
Background: Despite of the fact that nurses play a key role in caring for dying patients, nurses describe themselves as lacking confidence in providing care for the dying. Aim: This study sought to assess nurses’ perceived attitudes toward end-of-life nursing care. Further, the study aimed to assess whether a relationship exists between work setting and nurses’ attitudes toward end-of-life nursing care.
Introduction: Neuroendocrine carcinoma coexisted with adenocarcinoma in cervix is very rare. This disease have a very poor prognosis and so far no standard treatment has been obtained. Case Illustration: A 39-years-old woman seeks medical attention with chief complaint of bleeding outside of menstruation. Ultrasound: EL (+) enlarged portio with a mass of 3.8 cm × 2.7 cm.
Prognostic Significance of Aurora Kinase Expression and it’s Correlation with Other Apoptotic-like Proteins in Oral Tongue Squamous Cell Carcinoma
Background: Aurora kinases represent a family of serine/threonine kinases with an important role in cell division regulation. We evaluated the association of Aurora Kinase-A (AURKA) and Aurora Kinase-B (AURKB) with other apoptotic-like proteins, clinicopathological factors and survival in a cohort of Oral Tongue Squamous Cell Carcinoma (OTSCC) patients. Methods: AURKA, AURKB, P53 and Survivin expression using immunohistochemistry, with a cut-off point of 10% was performed in 100 OTSCC patients.
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