Maria Grazia Cerrito is currently a Senior Scientist at the University of Milano Bicocca in Italy.
Maria Grazia Cerrito is an active member of the American Association for Cancer Research (AACR). Her research interest has focused on assessing the impact of low-dose metronomic chemotherapy regimens in advanced breast cancer. She is also involved in the characterization of novel genes involved in the drug resistance of epithelial tumors and their use as therapeutic targets. Previously, her research activity has focused on studying the molecular and cellular mechanisms underlying the pathology of different inflammatory diseases.
Maria Grazia Cerrito is the author of 31 articles published in international journals and, she is also the author of several contributions at the congress.
- Lavitrano M, Farina L, Cerrito M.G., Giovannoni, R.Sperm-MediatedGeneticModifications.”Methods in molecularbiology(Clifton, N.J.)2066, pp. 125-132.
- Lavitrano M, Ianzano L, Bonomo S, Cialdella A, Cerrito M.G., Pisano F, Missaglia C, Giovannoni R, Romano G, McLean CM, Voest EE, D'Amato F, Noli B, Ferri GL, Agostini M, Pucciarelli S, Helin K, Leone BE, Canzonieri V, Grassilli E. “BTK inhibitorssynergize with 5-FU to treatdrug-resistant TP53-null colon cancers.J Pathol. 2019 Sep 13.
- Giordano F, Vaira V, Cortinovis D, Bonomo S, Goedmakers J, Brena F, Cialdella A, Ianzano L, Forno I, Cerrito M.G., Giovannoni R, Ferri G.L., Tasciotti E, Vincent S, Damarco F, Bosari S, Lavitrano M, Grassilli M. “P65BTK is a novelpotentialactionable target in KRAS-mutated/EGFR-wild typelung adenocarcinoma”Journal of Experimental and ClinicalCancerResearch.” Vol. 38, Issue 1, 14 June 2019
- Basile D, GerratanaL, Buonadonna A,KenGarattiniS, Perin T,GrassilliE, MioloG,Cerrito M.G.,Belluco C,Bertola G, De Paoli A, Cannizzaro R,LavitranoM, Puglisi F, andCanzonieri V. “Role of Bruton’sTyrosineKinase in Stage III ColorectalCancer”. Cancers Vol. 1 (6) 2019
- Sala L, Cirillo G, Riva G, Romano G, Giussani C, Cialdella A, Todisco A, Virtuoso A, Cerrito M.G., Bentivegna A, Grassilli E, Ardizzoia A, Bonoldi E, Giovannoni R, Papa M, Lavitrano M.“SpecificExpression of a New BrutonTyrosineKinaseIsoform (p65BTK) in the Glioblastoma GemistocyticHistotype”. Front MolNeurosci. 24;(12):2019.
- Cerrito M.G., De Giorgi M, Pelizzoni D, Bonomo SM, Digiacomo N, Scagliotti A, Bugarin C, Gaipa G, Grassilli E, Lavitrano M, Giovannoni R, Bidoli P, Cazzaniga ME.“Metronomic combination of Vinorelbine and 5Fluorouracil is able to inhibit triple-negative breast cancer cells. Results from the proof-of-concept VICTOR-0 study”. Oncotarget 8;9(44):2018.
- Chisci E, De Giorgi M, Zanfrini E, Testasecca A, Brambilla E, Cinti A, Farina L, Kutryb-Zajac B,Bugarin C, Villa C, Grassilli E, Combi R, Gaipa G, Cerrito M.G., Rivolta I, Smolenski RT, Lavitrano M, Giovannoni R.“Simultaneousoverexpression of human E5NT and ENTPD1 protects porcine endothelialcellsagainst H2O2-induced oxidative stress and cytotoxicity in vitro”.Free RadicBiolMed. (108): 2017.
- Formica F, Broccolo F, Cerrito M.G.“Minimal Extracorporeal Circulation and Minimally Invasive Valve Operations: Should They Be the Right Combination in the Future?”Ann Thorac Surg. 103(3): 2017.
- Conconi D, Redaelli S, Bovo G, Leone BE, Filippi E, Ambrosiani L, Cerrito M.G.,Grassilli E, Giovannoni R, Dalprà L, Lavitrano M.“Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients"Tumour Biol. 37(10): 2016.
- Salerno D, Beretta GL, Zanchetta G, Brioschi S, Cristofalo M, Missana N, Nardo L, Cassina V, Tempestini A, Giovannoni R, Cerrito M.G.,Zaffaroni N, Bellini T, Mantegazza F. “Platinum-BasedDrugs and DNA InteractionsStudied by Single-Molecule and Bulk Measurements”. 24;110(10): 2016.
- Romano G, Santi L, Bianco MR, Giuffrè MR, Pettinato MT, Bugarin C, Garanzani C, Savarese L, Leoni S, Cerrito M.G., Leone BE, Gaipa E, Grassilli E, Papa M, Lavitrano M, Giovannoni R. “The TGF-B pathwayisactivated by 5-fluorouracil treatment in drugresistantcolorectal carcinoma cells.”. Oncotarget.19;7(16):2016.
- Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito M.G.,Masiero L, Ianzano L, Giordano F, Cicirielli V, Narloch R, D’amato F, Noli B, Ferri FL, Leone, BE,Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M. “A noveloncogenic BTK isoformisoverexpressed in coloncancer and required for RAS-mediatedtransformation” Oncogene. 18;35(33):2016.
- Cinti A, De Giorgi M, Chisci E, Arena C, Galimberti G, Farina L, Bugarin C, Rivolta I, Gaipa G, Smolenski RT, Cerrito M.G., Lavitrano M, Giovannoni R. “Simultaneous Overexpression of Functional Human HO-1, E5NT and ENTPD1 Protects Murine Fibroblasts against TNF-a-Induced Injury In Vitro”. PLoSOne. 29;10(10), 2015.
- Grassilli E, Ianzano L, Bonomo S, Missaglia C, Cerrito M.G., Giovannoni R, Masiero L, Lavitrano M. “GSK3A isredundant with GSK3B in modulatingdrugresistance and chemotherapy-inducednecroptosis”. PLoSOne. 1;9(7), 2014.
- De Giorgi M, Pelikant-Malecka I, Sielicka A, Slominska EM, Giovannoni R, Cinti A, Cerrito M.G.,Lavitrano M, Smolenski RT. “Functional analysis of expression of human ecto-nucleoside triphosphate diphosphohydrolase-1 and/or ecto-5'-nucleotidase in pig endothelial cells”. NucleosidesNucleotidesNucleicAcids. 33(4-6):313-8, 2014.
- Busnelli M, Manzini S, Froio A, Vargiolu A, Cerrito M.G.,Smolenski RT, Giunti M, Cinti A, Zannoni A, Leone BE, Forni M, Bacci ML, Biasi GM, Giovannoni R, Lavitrano M. “Dietinducedmildhypercholesterolemia in pigs: local and systemicinflammation, effects on vascularinjury - rescue by high-dose statin treatment”.PLoSOne. 15;8(11), 2013.
- Andria B, Bracco A, Attanasio C, Castaldo S, Cerrito M.G.,Cozzolino S, Di Napoli D, Giovannoni R, Mancini A, Musumeci A, Mezza E, Nasti M, Scuderi V, Staibano S, Lavitrano M, Otterbein LE, Calise F. “Biliverdin protects against liver ischemia reperfusion injury in swine”.PLoS One 29;8(7), 2013.
- Tempestini A, Cassina V, Brogioli D, Ziano R, Erba S, Giovannoni R, Cerrito M.G., Salerno D, Mantegazza F. “Magnetic tweezers measurements of the nanomechanical stability of DNA against denaturation at various conditions of pH and ionic strength”. NucleicAcids Res. 1;41(3):2009-19, 2013.
- Radaelli A, Castiglioni P, Cerrito M.G., De Carlini C, Soriano F, Di Rienzo M, Lavitrano ML, Paolini G, Mancia G.” Infusion of Escherichia coli lipopolysaccharide toxin in rats produces an early and severe impairment of baroreflex function in absence of blood pressure changes”. Shock, 39(2):204-9, 2013.
- Lavitrano M, Giovannoni R, Cerrito M.G.,“Methods for sperm-mediated gene transfer”.Methods MolBiol, 927:519-29, 2013.
- Cerrito M.G.,Scagliarini A., Froio A., Liloia A., Busnelli M., Giovannoni R., Otterbein L.E.Mainetti L., Villa M., Bach F.H., Leone B.E., Biasi G.M., Lavitrano M.“Heme Oxygenase-1 Inhibition Prevents Intimal Hyperplasia Enhancing Nitric Oxide-Dependent Apoptosis of Vascular Smooth Muscle Cells”. Biological&PharmaceuticalBulletin, 34(8):1204-14, 2011.
- Vargiolu A., Manzini S., De Cecco M., Bacci M.L., Forni M., Galeati G., Cerrito M.G.,Busnelli M., Lavitrano M., Giovannoni R.“In Vitro Production of Multigene Transgenic Blastocysts via Sperm-Mediated Gene Transfer Allows Rapid Screening of Constructs to Be Used in Xenotransplantation Experiments”.TransplantProc, 42(6):2142-5, 2010.
- Busnelli M., Froio A., Bacci M.L., Giunti M., Cerrito M.G., Giovannoni R., Forni M., Gentilini F.,Scagliarini A., Deleo G., Benatti C., Leone B.E., Biasi G.M., Lavitrano M.“Pathogenetic role of hypercholesterolemia in a novel preclinical model of vascular injury in pigs”.Atherosclerosis, 207(2):384-90, 2008.
- Radaelli A.,Loardi C., Cazzaniga M., Balestri G., De CarliniC., Cerrito M.G.,Negrocusa E., Guerra L, Garducci S., Santo D.,Menicanti, L., Paolini G.,Azzellino A.,Lavitrano M., Mancia G., Ferrari A.U.,“Modulation of the acute inflammatoryresponse to on-pump coronary surgery by combined high dose pre-treatment with statins and ACE-inhibitors”.Arteriosclerosis, Thrombosis, and VascularBiology27(12): 2750-5,2007.
- Manzini S., Vargiolu A., Stehle I.M., Bacci M.L., Cerrito M.G., Giovannoni R., Zannoni A., Bianco M.R., Forni M., Donini P., Papa M., Lipps H.J., LavitranoM.“GeneticallyModifiedPigsProduced with a Non ViralEpisomalVector”ProcNatlAcad Sci U S A.21;103(47):17672-7, 2006.
- Galbaugh T., Cerrito M.G., Jose C. and Cutler M.L. “EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation”BMC Cell Biology, 19 (7): 34, 2006.
- Lavitrano M., Busnelli M., Cerrito M.G., Giovannoni R., Manzini S., and Vargiolu A.“Spermmediated gene transfer”ReprodFertil Dev.18: 1-5, 2006.
- Cerrito M.G.,Galbaugh T., Weihan W., Chopp T., Solomon D. and Cutler M.L.“Dominant Negative Ras enhances lactogenic hormone-induced differentiation by blocking activation of the Raf-Mek-Erk signal trasduction pathway”.J Cell Physiol. 201 (2): 244-58, 2004.
- Morano S., CiprianiR., Cerrito M.G., Santangelo C., Vasaturo F., Pantellini F., Sensi M., Guidobaldi L., Scarpa S. and Di Mario U.“Angiotensin-CovertingEnzymeInhibitionmodulates high-glucose-inducedextracellularmatrixchanges in mouse glomerular epithelial cells”.Nephron Exp Nephrol. 95 (1): 30-35, 2003.
- Scarpa S., Giuffrida A., Palumbo C., Coletti A., Cerrito M.G.,Vasaturo F., Sinibaldi P., Simonelli L., Procopio A. and Modesti A.“Retinoic acid inhibitsFibronectin and Lamininsynthesis and cellmigration of human pleuralMesothelioma in vitro”.Oncol Rep. 9 (1): 205-209, 2002.
- Cardelli P., Scarpa S., Cerrito M.G.,Barlattani A. and Modesti A.“L’ EGF sui fibroblasti gengivali umani”.Dental Cadmos 17: 41-47, 2000.
- Cerrito M.G., Giovannoni R, Grassilli E, Lavitrano M, Masiero L, Pisano F, Romano G, Methods of treating cancers. Patent application PCT/EP2014/066724, 2014.
- Cerrito M.G., Giovannoni R, Grassilli E, Lavitrano M, Masiero L, Pisano F, Romano G, Pharmaceutical kit for use in the treatment of colon and colorectalcancer. Patentapplication EP 2013179049.5, 2013.
- Co-principal investigator of "Control of Mammary Differentiation by Ras-dependent Signal Transduction Pathways" From Henry M. Jackson Foundation for Advancement of Military Medicine, Maryland, USA 2001-2004.
- Co-principal investigator of the research in collaboration with the cardiac surgery unit of the San Gerardo Hospital, Monza, Italy. "Role of cardiac miRNAs and systemic inflammatory response syndrome in the incidence of atrial fibrillation and myocardial injury after cardiac surgery: a single-center, prospective clinical trial" (mi RIAM). From 01-01-2016 to date.
