Opioid-induced hyperalgesia is a paradoxical state of nociceptive sensitization caused by exposure to opioids. Some patients who were receiving opioids for treating pain become more sensitive to certain painful stimuli. Its diagnosis may be confounded by a worsening pain pathology, withdrawal, or opioid tolerance. Several options in treating opioid-induced hyperalgesia include opioid reduction dosage, opioid rotating, or switching to a non-opioid adjuvant, such as ketamine or methadone.
- Volume: 2, Issue: 1
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Risk and Associated Product Recall Approach: Description of a Patient-Centered Multidisciplinary Information, Decision Aid and Support Structure
Introduction: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare form of cancer mainly associated with textured breast implants and tissue expanders recalled in early 2019 in Canada. Currently, there are no consensus and no shared best practices to approach the BIA-ALCL associated social and psychological implications. This article aims to share the CHU de Québec-Université Laval’s practice in taking its social responsibility and approaching the BIA-ALCL associated re...
In this perspective article, we review novel and unresolved concepts related to the biology of cancer metastasis that may be reasonably connected and resolved through the study of alterations in the gut microbiome. We hope this perspective generates discussion and a research agenda that contributes to our understanding of metastatic dormancy, the development of the pre-metastatic niche, and metastatic endurance.
Outcome of Cervical Cancer Patients Treated with Concomitant Chemoradiation Followed by Moderate Dose Rate Brachytherapy
Objectives: Cervical cancer is one of the common gynecological cancers that have high mortality and morbidity rate in developing countries because of late presentation due to lack of awareness programs and limited medical facilities. Brachytherapy is one of the modalities in its treatment. Much Data is available in the literature for Low Dose Rate (LDR) and High Dose Rate (HDR) Brachytherapy (BT) with little published data for Moderate Dose Rate (MDR) BT.
Use of a Commercially Available 12-Gene Assay in the Treatment of Early-Stage Colorectal Cancer: Results from a Nationally Representative Survey of U.S. Oncologists
Background: The Oncotype DX Colon Cancer Assay is a 12-gene assay that measures recurrence risk in stage II and III colorectal cancer patients that help oncologists make treatment decisions. Although adjuvant chemotherapy for patients with resected stage III colorectal cancer is routinely recommended, its benefit remains controversial in stage II colorectal cancer patients; thus, the real-world use of Oncotype DX Colon is of great clinical interest. The purpose of this study was to investigate ...
- Volume: 1, Issue: 3
Adenomyoepithelioma (AME) with myoepithelial carcinoma of the breast is rare and diagnosed following histological and immunohistochemical analysis. In the present case study, we describe a 38-year-old female patient with malignant AME with ultrasonographic and core biopsy findings. Histopathology revealed biphasic tubular proliferation and epithelial cells with atypical nuclei with obvious pleomorphism, hyperchromasia, and frequent mitosis. Overall Ki-67 proliferation index reached 30%. The pat...
A large number of genomic and post-genomic studies in this century have been conducted to provide insight into the molecular mechanisms of gastrointestinal carcinogenesis and precision medicine. However, the incidence and mortality associated with gastrointestinal cancer have been increasing in the higher age range. Here, this review presents preemptive medicine to delay or prevent the onset of gastrointestinal cancer through an intervention based on molecular biomarkers, including an individua...
- Volume: 1, Issue: 2
Extensive Refractory Isolated Multiple Nodal Recurrence of Ovarian Cancer Treated with Rapid Arc Radiotherapy Technique: A Case Series Study
Isolated nodal recurrence of ovarian cancer is infrequent. For selected patients cytoreductive surgery can improve the survival. The response rate for second line chemotherapy for recurrent ovarian cancer is around 50%–60%, 20%–30% and 10% in platinum-sensitive, platinum-resistant and platinum-refractory patients respectively. IMRT uses a computer algorithm to optimize dose to the target and minimize dose to organs at risk by modulating and shaping the beam either with static or dynamic beams.
In Extramedullary multiple myeloma, muscular involvement not adjacent to bone lesions (Especially multiple and diffuse) is rare. We report a case of multiple myleoma with multiple-diffuse muscle involvement confirmed by biopsy.
Prevalence and Patterns of Gastrointestinal Cancers among Obese Patients, from a Teaching Hospital in Saudi Arabia
Objective: To determine the prevalence and patterns of gastrointestinal (GI) cancers among obese and non-obese patients. Background: Obesity is associated with many comorbidities. Several studies concluded that there is an association between obesity and different types of cancers. But the prevalence and patterns of GI cancers among obese patients need to be investigated.
More than 100 types of papillomavirus have been identified so far, they are completely tissue-specific. About 5 of these infect the genital area from one person to another through sexual contact. Delayed proteins include L1 and L2, which form the virus capsid. Cervical cancer is the second most common cancer after breast cancer in women worldwide. Human papillomavirus (HPV) accounts for more than 2% of cervical cancers.Among them, about 15 carcinogenic genotypes have been identified as high-ris...
- Volume: 1, Issue: 1
Refining Immunotherapy of Human B-cell Non-Hodgkin’s Lymphoma by CD19 CAR T Cell: Current and Future Perspectives
Non-Hodgkin’s Lymphoma (NHL) is responsible for 4% of all cancer cases in the United States, but its conventional treatment options have experienced limited success. Patients develop resistances to the standard chemotherapy, CHOP, as well as Rituximab, a chemosensitizing agent used in concert with CHOP. Chimeric antigen receptor T cell (CAR-T cell) therapy may be a viable option for patients with refractory/relapsed NHL. In this new immunotherapy, a CAR is genetically added to the surface of T ...
Background and purpose: Stereotactic Ablative Radiotherapy (SART) has been associated with both impressive early responses and high rates of early-stage NSCLC control. This article reviews the overall survival, local control, toxicity and failure of SART in patients with early-stage NSCLC. Material and methods: The systematic review was performed following PRISMA guidelines. Survival outcomes were evaluated for early-stage NSCLC. Local control and toxicity outcomes were evaluated for any centr...
Background: Despite of the fact that nurses play a key role in caring for dying patients, nurses describe themselves as lacking confidence in providing care for the dying. Aim: This study sought to assess nurses’ perceived attitudes toward end-of-life nursing care. Further, the study aimed to assess whether a relationship exists between work setting and nurses’ attitudes toward end-of-life nursing care.
Introduction: Neuroendocrine carcinoma coexisted with adenocarcinoma in cervix is very rare. This disease have a very poor prognosis and so far no standard treatment has been obtained. Case Illustration: A 39-years-old woman seeks medical attention with chief complaint of bleeding outside of menstruation. Ultrasound: EL (+) enlarged portio with a mass of 3.8 cm × 2.7 cm.
Prognostic Significance of Aurora Kinase Expression and it’s Correlation with Other Apoptotic-like Proteins in Oral Tongue Squamous Cell Carcinoma
Background: Aurora kinases represent a family of serine/threonine kinases with an important role in cell division regulation. We evaluated the association of Aurora Kinase-A (AURKA) and Aurora Kinase-B (AURKB) with other apoptotic-like proteins, clinicopathological factors and survival in a cohort of Oral Tongue Squamous Cell Carcinoma (OTSCC) patients. Methods: AURKA, AURKB, P53 and Survivin expression using immunohistochemistry, with a cut-off point of 10% was performed in 100 OTSCC patients.
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